The Russian Direct Investment Fund (
The heterogeneous boosting approach (“vaccine cocktail” using human adenovirus serotype 26 as the first component and human adenovirus serotype 5 as the second component) was at the core of Sputnik V, the world’s first registered vaccine against coronavirus. With this approach proving successful in creating a longer and more durable immunity against the coronavirus, RDIF took the lead in initiating partnerships with other vaccine producers to conduct joint studies of a combination of the first component of Sputnik V with foreign vaccines. The first partnership of this kind was concluded in December 2020 between RDIF, The Gamaleya Center, AstraZeneca and R-Pharm and studies began in February 2021.
To date, the data of 121 volunteers corresponding to the Sputnik V combination groups were analyzed in the following regimens: Sputnik Light/AstraZeneca, Sputnik Light/Moderna, Sputnik Light/Sinopharm, Sputnik Light/Sputnik Light compared to control group Sputnik V 1 Comp./Sputnik V 2 Comp.
Sputnik Light vaccine is tested in Argentina in combination with other vaccines both as the first injection (primer) and the second one (booster shot). The data collected by the Ministry of Health of the Buenos Aires province demonstrates that both the combination of Sputnik Light with other vaccines and vaccination with two injections of only Sputnik Light shows high safety profile with no serious adverse events related to vaccination. All of the combinations studied are safe.
Kirill Dmitriev, CEO of the Russian Direct Investment Fund (RDIF), said:
RDIF was the first in the world to offer vaccine cooperation to other producers to conduct joint mix&match studies. This approach is the most promising one to fight the pandemic and new strains of coronavirus emerging around the world. The Sputnik Light vaccine can be effectively used in combination with other vaccines which is proven by studies in Argentina and other countries. RDIF is ready to partner with other producers for further mix&match studies in other parts of the world.
Key advantages of Sputnik Light:
- Sputnik Light is the first component (recombinant human adenovirus serotype number 26 (rAd26)) of Sputnik V – the world’s first registered vaccine against coronavirus.
- An efficacy level of almost 80% is higher than that of many two-dose vaccines.
- Sputnik Light has proven effective against all new strains of coronavirus, as demonstrated by the Gamaleya Center during laboratory tests.
- Sputnik Light is compatible with standard vaccine storage and logistics requirements.
- The Sputnik Light vaccine is based on a well-studied human adenoviral vector platform that has proven to be safe and effective, with no long-term side effects, as confirmed in over 250 clinical trials conducted globally over the past two decades (while the history of use of human adenoviruses in vaccine development started in 1953).